منابع مشابه
Glial cells and chronic pain.
Over the past few years, the control of pain exerted by glial cells has emerged as a promising target against pathological pain. Indeed, changes in glial phenotypes have been reported throughout the entire nociceptive pathway, from peripheral nerves to higher integrative brain regions, and pharmacological inhibition of such glial reactions reduces the manifestation of pain in animal models. Thi...
متن کاملRole of satellite glial cells in gastrointestinal pain
Gastrointestinal (GI) pain is a common clinical problem, for which effective therapy is quite limited. Sensations from the GI tract, including pain, are mediated largely by neurons in the dorsal root ganglia (DRG), and to a smaller extent by vagal afferents emerging from neurons in the nodose/jugular ganglia. Neurons in rodent DRG become hyperexcitable in models of GI pain (e.g., gastric or col...
متن کاملThe Role of Glial Cells in Chronic Pain
INTRODUCTION Pain management remains a significant health concern, especially for those who suffer from chronic pain. Also known as neuropathic pain, this type of pain usually follows injury, surgery, infection, or chemotherapy (Marx, 2004). Chronic pain, or pain that persists beyond the natural course of healing, affects over five million people in the United States (Tawfik et al., 2007) and c...
متن کامل[Satellite glial cells in sensory ganglia: its role in pain].
BACKGROUND AND OBJECTIVES Satellite glial cells in sensory ganglia are a recent subject of research in the field of pain and a possible therapeutic target in the future. Therefore, the aim of this study was to summarize some of the important physiological and morphological characteristics of these cells and gather the most relevant scientific evidence about its possible role in the development ...
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ژورنال
عنوان ژورنال: Neuron Glia Biology
سال: 2007
ISSN: 1740-925X,1741-0533
DOI: 10.1017/s1740925x08000100